Chronic Fatigue Syndrome Is Real: Stanford Researchers ID Biomarkers

Chronic Fatigue Syndrome Is Real: Stanford Researchers ID Biomarkers

By Staff.

People with chronic fatigue syndrome (also known as myalgic encephomyelitis) have had a tough time being diagnosed, treated and even believed by physicians, coworkers and family.  The syndrome is characterized by having long-term, extreme fatigue and pain, and has no known cure.

But, new research may lead to definitive diagnosis, and perhaps a better understanding of the syndrome.

The following is a news story by Bruce Goldman with the Stanford Medical School’s Office of Communication & Public Affairs.

Researchers at the Stanford University School of Medicine have linked chronic fatigue syndrome to variations in 17 immune-system signaling proteins, or cytokines, whose concentrations in the blood correlate with the disease’s severity.

The findings provide evidence that inflammation is a powerful driver of this mysterious condition, whose underpinnings have eluded researchers for 35 years.

The findings, described in a study published online July 31 in the Proceedings of the National Academy of Sciences, could lead to further understanding of this condition and be used to improve the diagnosis and treatment of the disorder, which has been notably difficult.

More than 1 million people in the United States suffer from chronic fatigue syndrome, also known as myalgic encephomyelitis and designated by the acronym ME/CFS. It is a disease with no known cure or even reliably effective treatments. Three of every four ME/CFS patients are women, for reasons that are not understood. It characteristically arises in two major waves: among adolescents between the ages of 15 and 20, and in adults between 30 and 35. The condition typically persists for decades.

“Chronic fatigue syndrome can turn a life of productive activity into one of dependency and desolation,” said Jose Montoya, MD, professor of infectious diseases, who is the study’s lead author. Some spontaneous recoveries occur during the first year, he said, but rarely after the condition has persisted more than five years.

The study’s senior author is Mark Davis, PhD, professor of immunology and microbiology and director of Stanford’s Institute for Immunity, Transplantation and Infection.

“Solid basis for a diagnostic blood test”

“There’s been a great deal of controversy and confusion surrounding ME/CFS – even whether it is an actual disease,” said Davis. “Our findings show clearly that it’s an inflammatory disease and provide a solid basis for a diagnostic blood test.”

Many, but not all, ME/CFS patients experience flulike symptoms common in inflammation-driven diseases, Montoya said. But because its symptoms are so diffuse – sometimes manifesting as heart problems, sometimes as mental impairment nicknamed “brain fog,” other times as indigestion, diarrhea, constipation, muscle pain, tender lymph nodes and so forth – it often goes undiagnosed, even among patients who’ve visited a half-dozen or more different specialists in an effort to determine what’s wrong with them.

Montoya, who oversees the Stanford ME/CFS Initiative, came across his first ME/CFS patient in 2004, an experience he said he’s never forgotten.

“I have seen the horrors of this disease, multiplied by hundreds of patients,” he said. “It’s been observed and talked about for 35 years now, sometimes with the onus of being described as a psychological condition. But chronic fatigue syndrome is by no means a figment of the imagination. This is real.”

Antivirals, anti-inflammatories and immune-modulating drugs have led to symptomatic improvement in some cases, Montoya said. But no single pathogenic agent that can be fingered as the ultimate ME/CFS trigger has yet been isolated, while previous efforts to identify immunological abnormalities behind the disease have met with conflicting and confusing results.

Still, the sporadic effectiveness of antiviral and anti-inflammatory drugs has spurred Montoya to undertake a systematic study to see if the inflammation that’s been a will-o’

-the-wisp in those previous searches could be definitively pinned down.

To attack this problem, he called on Davis, who helped create the Human Immune Monitoring Center. Since its inception a decade ago, the center has served as an engine for large-scale, data-intensive immunological analysis of human blood and tissue samples. Directed by study co-author Holden Maecker, PhD, a professor of microbiology and immunology, the center is equipped to rapidly assess gene variations and activity levels, frequencies of numerous immune cell types, blood concentrations of scores of immune proteins, activation states of intercellular signaling models, and more on a massive scale.

To continue reading the rest of Bruce Goldman’s article, please click here.

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Authored by: Staff

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Judy, thank you soooo much for posting that very informative link! I’m studying today :). Your story is my story.
I’m finding a problem with managing the combo of having chronic spine pain and CFS. It’s a catch 22. If I’m in heightened back pain it’s difficult for me to exercise to help the fatigue and if I’m extremely fatigued it’s also difficult to do ANYTHING but rest/sleep. But, I’m trying to figure it all out.
I saw a Rheumatologist 3 days ago for the 1st time ever re: the increase in my fatigue.
He was kind but is fresh out of his fellowship just 3 wks (had I known!) and I think he was overwhelmed with my issues and suggested I see a therapist. I left him feeling even more discouraged. I don’t need a therapist, I need a proper diagnosis. May God help keep us all in higher spirits, this is so not easy!


I’ve been living with chronic low back pain (mostly untreated) for 25+ years now. Inflamation comes along with the pain. A few years ago I started experiencing “brain fog”, lack of concentration, extreme exhaustion, absolutely NO energy, un-refreshing sleep….and many more symptoms of ME/CFS. I’ve never been “officially” diagnosed because of lack of knowledge by the medical community. Not long ago The National Pain Report published an article mentioning a CFDS & Fibro online Self-Help website. It’s been extremely helpful & informative. You can register & pay for an online class or you can do a FREE Self-Help course on your own time, at your own pace. I encourage everyone with Chronic Fatigue or Fibro to check it out….go to


Hi Eric, sorry to hear you are so sick. I have had this since the mid 90’s. It is a terrible way to live & I really know your pain. I haven’t been to a family function in approx. 12 years. I have Multiple Chemical Sensitivity illness with it & people think you make it up because you have no wounds. There is a website, Google Linda Sepp, if you are interested and she has a lot of help on her site. Best wishes and hope you find some relief.


Ditto on Eric’s comment. I’ve been hit hard this year with CP and ME/CFS and have been doing a ton of research. My life has shut down. And I’m sad because of it. I’m having a really tough day today and having been praying for myself and others with this illness.
Ed/staff… Thank you for this post…it helps me emotionally to at least know that more research is being done on it.


REAL evidence? I would have “thought” that chronic fatigue resulting with pain was a million patient conspiracy to make appointments with doctor after doctor, spending money for visits and time lost, and still retain no results.Does patient testimony based on evident loss of “work”, possibly oversleeping, exhaustion, and reduced social activity not count for……anything? Like fibromyalgea and other neuropathy related symptoms.


I was called a quack, by many doctors and nurses, after making the diagnoses, over ten years ago!, Thing is, since I suffered from the symptoms and trigger pints, I know more about it than 99% of the doctors and nurses in the areas that I worked, many, many, years ago! But, they eventually forced me out. It does not pay to know more than most of your, narrow minded, “colleagues”! I took care of several males, one who was told, “Men do not get it”!


Thank you for posting on ME/CFS, it is an extremely exhausting, disabling and painful condition. On any given day I feel like I am dying and need to goto the emergency room. I have been bedbound and in chronic pain and unable to do anything for almost 6 years.