Lyrica Fails in Pain Studies

Lyrica Fails in Pain Studies

A drug currently used to treat fibromyalgia and other chronic pain disorders is not effective in reducing neuropathic pain caused by HIV infection or diabetes, according to the drug’s manufacturer.

Pfizer ordered a halt to two phase III studies after preliminary results showed that pregabalin, which is sold under the brand name Lyrica, was no more effective than a placebo.

In the HIV neuropathy study, an interim analysis was conducted after 246 patients were given either Lyrica or a placebo.

“The results revealed that the improvements in neuropathic pain symptoms in this study were virtually identical between the Lyrica and placebo treatments,” Pfizer said in a statement. The drug maker said no safety issues were raised.

The other phase III study evaluated Lyrica as therapy for 665 patients who had not responded to earlier treatment for peripheral diabetic neuropathy.  All patients were given Lyrica for 6 weeks and then switched to either a placebo or continued using Lyrica for 13 weeks.

Pfizer said that patients who took Lyrica continued to show improvements, but they were not significantly different from those seen in the placebo group. Side effects from taking Lyrica included peripheral edema, dizziness, somnolence and upper respiratory tract infection. The symptoms are consistent with what is already known for Lyrica.

Pfizer said further analysis will be conducted on the initial results from the two studies. Lyrica is already approved in the U.S.for treatment of diabetic peripheral neuropathy, a form of nerve damage characterized by burning pain, pins and needles, or shooting pain in the feet and hands. About 20% of people with diabetes experience pain from nerve damage.

Lyrica was the first medication approved by the Food and Drug Administration for the treatment of fibromyalgia. The drug is also used to treat pain from shingles and seizures in adults with epilepsy.

Authored by: Pat Anson, Editor

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vee

I find this strange because I thought that anti seizure medication helped with pain due to calming the brain.
I wonder IF there are SOME who are helped with Lyrica or does this mean just NOT ENOUGH Patients were helped?

Renee

I have been on Lyrica for the past 4.5 years for RSD/CRPS. I have tried Neuroton (how ever it’s spelled) and really it made no difference in my pain but the Lyrica has. However, my best friend has had the opposite results with her chronic pain. I wonder how much of it has to do with each person’s chemical make up? Because we are without insurance, I often have to wait to refill because it is so expensive so when I run out within a few days the skin sensitivity and lightning bolts in my knee comes back but it take a week or more to get back to the full Monty of pain. What sucks is the drag you feel when restarting it but after a week or two I am back to fully functioning. I know several people that can’t wait it out for the fog to lift, when starting it for the first time it took almost a month for me to adjust to the side effects so I could function again.

Stephanie

Hi: I am taking Lyrica for RSD and not sure it is working for the pain. However, the side affects of dizzyness were awful and even though the Doctor wanted me to continue on the higher strength I kept decreasing it as I could not function and was off balance. How is one supposed to know what is working when they are also on percocet for the pain. Pain management strongly believes in Lyrica and says it is helping. I have had nerve blocks and those helped with the burning and some of the pain, which is in my hand from shoulder surgery; but the swelling, throbbing, sometimes feeling like I have glass slivers and what feels like small pebbles that can be moved around but they hurt. This is what I go through everyday and it is a year since my surgery and I am going for hand therapy to keep my fingers from getting stiff; however I did lose the muscle tone in my palm. Not sure what else I can do to get help?

esmeralda

I STARTED LYRICA 1YR AND 6MONTHS AGO FOR FYBROMYALGIA PAIN. WORKED FOR FIRST 2 MONTHS AND THEN NOTHN. JUST STOPPED WORKING. I HAVE KEPT TAKN IT DUE TO MY DOCTOR’S REQUEST WHILE I FIND SUMTHN ELSE TO REPLACE IT. SHE SAYS IF I GO OFF IT W/O HAVN SUMTHN TO TAKE ITS PLACE THEN I AM GOIN TO FEEL EVEN WORSE THAN I DO NOW. UMMM SHOULDNT SHE HAVE LET ME KNOW THIS IN THE FIRST PLACE. I AM SO MAD THAT THEY GET U TO TAKE THIS MED THAT IS SUPPOSED TO HELP BUT ENDS UP MAKN U WORSE IN THE END. THEY WONT TELL U THIS UP FRONT BUT I KNOW FOR ALOT OF PPL IN SO MUCH PAIN THEY ARE WILLN TO TAKE IT AND RISK THE WORSE IN ORDER TO HAV ETHE BEST RESULT THEY ARE HOPN FOR. THAT IS WHY ALL THESE DRUG COMPANIES KEEP TAKN ADVANTAGE OF US BECUZ THEY KNOW WE ARE WILL TO TRY AND RISK ANYTHING FOR RELIEF FROM WHAT AILS US. THIS IS WHERE THE GOVT NEEDS TO GET MORE INVOLVED. YES I KNOW IT TAKES BILLIONS OF DOLLARS FOR RESEARCH AND PRODUCTION OF MEDICATIONS BUT THEY ALSO HAVE BILLIONS OF NEVER ENDING CONSUMERS THAT ARE HERE NOW AND BORN EVERYDAY.

Debbie Frohna

someone had this on their PN facebook stuff. I actually found this to be very interesting. Very. Since when did Lyrica fail in diabetic neuropathy? Isn’t it just beefed up gabapetin?