New Botox Injection Could Relieve Pain for Months

New Botox Injection Could Relieve Pain for Months

A single injection of modified Botox could relieve pain from migraines, arthritis and back pain for months without any side effects, according to UK researchers.

bigstock-Professional-doctor-with-medic-17573543Botox is best known for smoothing out facial wrinkles, but its pain relieving qualities are increasingly being recognized.

Researchers at the University of Sheffield have created a modified version of Botox by combining the neurotoxins Clostridium botulinum and Clostridium tetani.

Botuilin is the main ingredient in Botox and works by preventing nerve cells from communicating with muscles – which prevents wrinkles from forming.

Clostridium tetani – also known as the tetanus bug targets the central nervous system and helps ferry the combined toxin to the spinal cord, where it stops pain signals from being transmitted to the brain.

“Currently painkillers relieve lingering pain only temporarily and often have unwanted side effects. A single injection of the new molecule at the site of pain could potentially relieve pain for many months in humans and this now needs to be tested,” said Professor Bazbek Davletov of Sheffield University, who believes the modified Botox could be used to treat several neurological disorders, including chronic pain and epilepsy.

“We hope that the engineered molecule could improve the quality of life for those people who suffer from chronic pain. We are now negotiating transfer of the technology to a major pharmaceutical company,” he said.

The study is featured on the cover of the journal Bioconjugate Chemistry.

Botox received approval from the Food and Drug Administration for the treatment of chronic migraines in 2010. Injections are made into the head and neck to relieve migraine pain. Botox is also used to treat muscle spasms and excess sweating. The global Botox market is forecast to reach $2.9 billion by 2018.[

Critics say not enough is known about the long term effects of Botox to justify its widespread use. Botox has been linked to respiratory failure and death.

The FDA requires the drug to have a boxed warning cautioning that the effects of the botulinum toxin may spread from the area of injection to other areas of the body, causing symptoms similar to botulism.

Authored by: Pat Anson, Editor

There are 4 comments for this article
  1. Janice Reynolds RN, BC, OCN, CHPN at 8:47 am

    It will not be the “answer” for Chronic Pain as there as many different persistent pain syndromes caused by or the result of many different reasons (is the long term pain resulting from trauma the same as that from alkylating spondylitis or arthritis or TMJ or CRPS, etc. The other issue, the poison from the sea snail which is a pain reliever (Prialt) for neurological pain is one of last resort because of cost and serious adverse effects. Would the cost of this be extreme as well?

  2. Stephen S. Rodrigues, MD at 10:49 am

    @Karen, that is unfortunate that you tried all that you have stated and are still in pain. I do think we will uncover a “cure” but not in a single “fix” or pill. Therapy should help and should be continued forever because it is designed to activate innate healing and nature should “heal” your body.

    When I get a new patient who has tried everything I will use my simple cooking analogy to see where healing is broken. Like making biscuits, you need fresh ingredients, proportioning is important, kneading and baking for the correct time and temperature. Vitamins, Magnesium and Lithium are some of the ingredients; Life-work-stress balance is proportioning; if your kneading or bodywork therapy is too gently or infrequent then all the ingredients will not mix and marry properly; and sleep, quality and amount are also vital. Your cells will know if there is not enough magnesium or the proper sleep because the “biscuits” will be flat and pale. You can’t cheat any of these steps in this process.

    I figured out that all Acupuncture, Acupuncturists, Doctors or Therapist are NOT equal so I would suggest finding other opinions and providers. Having all these therapeutic options is a plus because you can do some at home and you can pick the best options to tailor make your own plan of action.

  3. Karen at 9:56 pm

    I’ve suffered from migraines for nearly 50 years. I’ve tried diet modifications, exercise, meditation, yoga, acupuncture, endless doctor visits and different meds, hypnotherapy… nothing has worked. The one thing that all of my doctors agree on is that no one approach works for everyone. Until a real “cure” is found, each new treatment promises hope for those of us with chronic migraines. I will be watching to see how this one works.

  4. Stephen S. Rodrigues, MD at 3:58 pm

    Botox works, but for all the wrong reasons! It is being used in place of effective safe, more natural and possibly curative therapy. In the long run, Botox use will be detrimental to a patient’s ongoing medical problems, health and wellbeing. Botox works by paralyzing muscles, so if you paralyze an erratic muscle full of trigger points and myofascial disease, you will give the patient a short lived reprieve from the pain and dysfunction. The problem is that the diseased muscle will recover and once active, will wreak havoc again.

    The most natural, innate form of care for the body; muscles, connective tissue disease, neuropathy, arthritis, arthralgia, Fibromyalgia, vascular, dysfunction and conundrums is with Therapy! THERAPY is in a recipe of Vits, Minerals, trace elements, wellness, mindfulness, massage, heat, zumba, yoga and most important Myofascial Release Therapy with hands-on release modalities and release with needles.