Pregabalin Reduces Pain and Improves Sleep for People with Fibromyalgia

Pregabalin Reduces Pain and Improves Sleep for People with Fibromyalgia

Pregabalin reduced pain and improved quality of sleep among fibromyalgia sufferers and improving sleep quality among patients with fibromyalgia, according to data published in Current Medical Research and Opinion.

“Pregabalin is a therapy approved for the treatment of [fibromyalgia (FM)-related] pain in multiple countries worldwide, and its efficacy for the treatment of FM-related pain has been demonstrated in several double-blind, randomized, placebo-controlled clinical trials,” said Andrew Clair, PhD, and Birol Emir, PhD, in a press release.

“These clinical trials enrolled subjects with moderate or severe FM pain at baseline; however, determining differences in the efficacy and safety of pregabalin stratified by disease severity was not a prespecified analysis. Moreover, we are not aware of any other studies that have evaluated the efficacy or safety of pregabalin for FM-related pain by differences in baseline pain in severity categories (e.g., moderate vs. severe),” they added.

The researchers collected data from five randomized, double-blind, placebo-controlled phase 3 clinical trials to determine efficacy through 12 weeks.  Adults in the trials were diagnosed with FM and had either moderate pain (4-6 on 11 point rating scale) or severe pain (7-10), and were treated with 300 mg to 450 mg of pregabalin.

A total of 1,605 participants were treated with pregabalin and 929 were given placebo. All participants taking the drug self-reported a reduction in pain and improvement in sleep quality from week 8 through week 12 (P < .01).  There was greater improvement in both pain and sleep quality for those whose baseline was severe and were treated with the medication (p < .01).

“Pregabalin was found to be efficacious and generally well tolerated as a treatment for reducing pain in subjects with FM regardless of baseline pain severity,” Clair and Emir wrote.

“These reductions in pain appeared greater in subjects with severe compared with moderate baseline pain, whereas the incidence of [adverse effects] remained consistent with the known safety profile of pregabalin and was comparable between subjects, irrespective of baseline pain severity.”

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Authored by: Staff

There are 7 comments for this article
  1. michael wagner at 12:44 pm

    I bought a lift chair off the internet , come to find out the seller was a retired disabled pharmacist , he told me he took large amounts of lyrica and it stopped the pain for a day or so, but he said you cant take it on a regular basis as it don’t work, I had some left over from years back and I tried his way, believe it or not he was right, I felt good but the days not taking lyrica were horrible as the nice days were rare.

  2. Sandra Gayle at 11:40 am

    Well here we go. All the new pain medication will be coming out that most can,t afford. But guess who is going to make money off the people …the same ones behind pushing pain pills being addictive for the poor people. If you watch long enough you will always see a dollar bill behind things. Big Pharmaceutical companies. I just hate them. Don,t care about people.

  3. Sheri at 6:16 pm

    I can’t understand how all this new-fangled stuff gets approved? The side effects are crazy!

  4. Connie at 12:35 pm

    Sadly, I too believed the study and tried it. I had no improvement in pain and gained over 30lbs in just under 3 months. It took a lot to get off Lyrica, because the withdrawals symptoms were brutal.
    I have, since then, read the more comprehensive study that proved Lyrica does NOT relieve neuropathic pain. I’ve also seen some the legal actions due lies that the company told to the FDA, while getting the drug approved.
    It’s prudent to only believe the studies that are conducted by those not associated with the manufacturer.

  5. Rob at 11:23 am

    Lyrica is not the answer for all of us suffering from fibromyalgia. It caused weight gain and other problems for me, not the least of which was suicidal thoughts. This report appears to be very one-sided. I took Lyrica for well over a year, and it just created more and more problems for me> I wanted it to work so much!!! Please, read online patient comments about it if you are considering taking Lyrica for any condition.

  6. Richard A. Lawhern, Ph.D. at 7:26 am

    As a patient advocate for facial neuralgia patients, I fairly often talk with people prescribed pre-gabalin (generic for the brand name Lyrica). Anyone taking this medication should be advised that it is NOT a fire-and-forget drug.

    As noted on rxlist.com, “In premarketing controlled trials of all populations combined, 14% of patients treated with LYRICA and 7% of patients treated with placebo discontinued prematurely due to adverse reactions. In the LYRICA treatment group, the adverse reactions most frequently leading to discontinuation were dizziness (4%) and somnolence (4%). In the placebo group, 1% of patients withdrew due to dizziness and < 1% withdrew due to somnolence. Other adverse reactions that led to discontinuation from controlled trials more frequently in the LYRICA group compared to the placebo group were ataxia, confusion, asthenia, thinking abnormal, blurred vision, incoordination, and peripheral edema (1% each)."

    In my communications with patients using Lyrica, I have also heard a few reports from people who experienced vivid and terrifying dreams while taking the medication. These reports do not appear to be reflected in clinical data I have read from authoritative sources. But vivid dreams are reported in multiple patient forums online.

    While I am not a physician, it seems prudent for anyone considering this medication to counsel with their primary care providers concerning active monitoring of their outcomes during the first few months of their use.

  7. Sherry G at 5:56 am

    I am VERY Leary of a study that states “ALL participants receiving the drug reported a reduction in pain”. I too, have severe pain from fibromyalgia and pregamblin did nothing for my pain yet caused weight gain, which adds to my pain. Let’s not forget 2 things: We are all different in our pain and activity levels, and the side effects can sometimes be worse than the pain. I find this study to be extremely skewed in its’ findings and IF it were THAT great, wouldn’t we ALL be taking it??!!