People suffering from complex regional pain syndrome (CRPS) gain meaningful limb pain relief with dorsal root ganglion (DRG) stimulation as opposed to traditional spinal cord stimulation (SCS), a new study says.
CRPS is a very painful condition that most often affects one of the limbs after an injury or trauma.
152 patients were enrolled in the ACCURATE study at 22 U.D. centers. Patients were randomized to receive either DRG stimulation or traditional SCS therapy. The study’s findings, which were presented at the North American Neuromodulation Society’s 2015 Meeting, include:
- A statistically significantly number of patients receiving DRG stimulation achieved meaningful pain relief and greater treatment success when compared to patients receiving traditional SCS (74.2 % vs. 53 %).
- Nearly all patients receiving DRG stimulation reported better targeting of their pain without extraneous paresthesia than patients receiving traditional SCS (94.5 % vs. 61.2 %).
- More than a third of patients who received DRG stimulation were experiencing greater than 80 percent pain relief with no paresthesia.
“Patients battling complex regional pain syndrome and peripheral causalgia have very few options, and we believe DRG stimulation will provide a meaningful treatment option to patients suffering from these conditions,” said Allen Burton, M.D., medical director of neuromodulation and vice president of medical affairs at St. Jude Medical.
The ACCURATE study is largest study to date to evaluate people suffering from chronic lower limb pain associated with complex regional pain syndrome (CRPS), according to St. Jude Medical, whose product, the Axium System, is being evaluated in the study.
Complex regional pain syndrome (CRPS), also known as, reflex sympathetic dystrophy syndrome (RSD), is described by National Pain Report partner, RSDSA, this way:
“CRPS/RSD is a chronic neuro-inflammatory disorder. It is classified as a rare disorder by the United States Food and Drug Administration. However, up to 200,000 individuals experience this condition in the United States, alone, in any given year.
CRPS occurs when the nervous system and the immune system malfunction as they respond to tissue damage from trauma. The nerves misfire, sending constant pain signals to the brain. The level of pain is measured as one of the most severe on the McGill University Pain Scale.
CRPS generally follows a musculoskeletal injury, a nerve injury, surgery or immobilization.
The persistent pain and disability associated with CRPS/RSD require coordinated, interdisciplinary, patient-centered care to achieve pain reduction/cessation and better function.”