Depression and Painkiller Use Increases Risk of Addiction after Surgery

Depression and Painkiller Use Increases Risk of Addiction after Surgery

The risk of addiction to opioid painkillers after surgery significantly increases if a patient is depressed or has used pain medications prior to surgery, according to a pilot study at Stanford University. Researchers found that psychological risk factors were a better predictor of long-term opioid use after surgery than pain itself.

The study is being published in Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society.

Over a hundred patients were enrolled in the study prior to undergoing breast cancer or joint replacement surgery. Patients were asked about their history of depression, previous use of opioids, and self-perceived risk of addiction.

After their surgeries, each patient’s pain levels were assessed daily, along with their use of prescribed opioids, such as morphine.

“As patients recover from surgery, they face an ongoing choice either to continue taking prescribed opioids or to stop opioids and undertake non-opioid pain treatment,” said lead author Dr. Ian Carroll.

About 6 percent of the patients were still taking opioids 150 days after their surgeries. The ones with three prior risk factors were more likely to be in that group:

  • Patients who had use opioids for pain relief before their operations were 73% more likely to use them long term after surgery.
  • Patients who rated themselves at risk of addiction were 53% more likely to use opioids long term.
  • Patients with symptoms of depression had a 42% higher risk of long term use.

“Each of these factors was a better predictor of prolonged opioid use than postoperative pain duration or severity,” said Carroll, who added that preoperative risk factors were significant no matter what type of surgery the patient had.

The researchers say if just 6% of Americans who had surgery every year became long term opioid users, that would amount to 1.1 million new users annually.

Authored by: Pat Anson, Editor

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It would be really good if journalists sometimes actually read the studies, not just press releases, on which they are reporting. First, this study says nothing about postsurgical addiction to opioid analgesics, this wasn’t even measured; second, the “risk of addiction” rating was inadequately defined and not a validated assessment; and, third, this was an underpowered pilot study and the quality of evidence was very low. There is much more that was wrong with this study, but, in short, it makes much ado about very little in the way of proof.