In a study of monkeys where cannabinoids with morphine were combined, there was not a significant increase in impulsivity or memory impairment. These findings suggest that using opioids and marijuana together could offer a safe way to cut opioid dosage among patients suffering from pain, and may reduce their risk of opioid addiction.
“These data provide additional evidence supporting the notion that opioid-cannabinoid mixtures that are effective for treating pain do not have greater, and in some cases have less, adverse effects compared with larger doses of each drug alone,” said Vanessa Minervini, PhD, a postdoctoral fellow at the University of Texas Health Science Center at San Antonio.
This research will be presented at the American Society for Pharmacology and Experimental Therapeutics annual meeting April 6-9 in Orlando, Florida.
Previous studies have suggested the cannabinoids in marijuana enhance some of the pain-relieving effects of opioid drugs but do not enhance effects related to addiction and overdose. However, both drugs individually are known to impair cognition, leading to a concern that such side effects could be amplified if opioids and marijuana are used together. Researchers say the new study offers encouraging evidence this is not the case.
“The current opioid epidemic underscores the need for safe and effective pharmacotherapies for treating pain,” said Minervini. “Combining opioid receptor agonists with drugs that relieve pain through actions at non-opioid mechanisms (for example, cannabinoid receptors) could be a useful strategy for reducing the dose of opioid needed to achieve pain relief.”
The researchers gave several monkeys moderate doses of morphine and CP55940, a synthetic drug that mimics the activity of the tetrahydrocannabinol (THC) naturally found in marijuana. They assessed impulsivity and memory with tests involving touch screens and treats. The results showed each drug impeded performance and that giving the monkeys both drugs together had a lessened effect on performance than either drug alone.
While clinical trials need to be conducted to confirm whether these results translate to humans, monkeys tend to process drugs similarly to humans and are considered a good model for cognition.